Electrostatic distance geometry in a K+ channel vestibule.
نویسندگان
چکیده
منابع مشابه
Electrostatic interactions of S4 voltage sensor in shaker K+ channel
The S4 segment comprises part of the voltage sensor in Shaker K+ channels. We have used a strategy similar to intragenic suppression, but without a genetic selection, to identify electrostatic interactions of the S4 segment that may be important in the mechanism of voltage-dependent activation. The S4 neutralization mutations K374Q and R377Q block maturation of the protein, suggesting that they...
متن کاملConotoxins as Sensors of Local pH and Electrostatic Potential in the Outer Vestibule of the Sodium Channel
We examined the block of voltage-dependent rat skeletal muscle sodium channels by derivatives of mu-conotoxin GIIIA (muCTX) having either histidine, glutamate, or alanine residues substituted for arginine-13. Toxin binding and dissociation were observed as current fluctuations from single, batrachotoxin-treated sodium channels in planar lipid bilayers. R13X derivatives of muCTX only partially b...
متن کاملOn the k-nullity foliations in Finsler geometry
Here, a Finsler manifold $(M,F)$ is considered with corresponding curvature tensor, regarded as $2$-forms on the bundle of non-zero tangent vectors. Certain subspaces of the tangent spaces of $M$ determined by the curvature are introduced and called $k$-nullity foliations of the curvature operator. It is shown that if the dimension of foliation is constant, then the distribution is involutive...
متن کاملInteractions between a Pore-Blocking Peptide and the Voltage Sensor of the Sodium Channel: An Electrostatic Approach to Channel Geometry
Few experimental data illuminate the relationship between the molecular structures that mediate ion conduction through voltage-dependent ion channels and the structures responsible for sensing transmembrane voltage and controlling gating. To fill this void, we have used a strongly cationic, mutated mu-conotoxin peptide, which only partially blocks current through voltage-dependent sodium channe...
متن کاملEffect of channel geometry on the electrostatic potential in acetylcholine channels.
We study the effect of channel geometry on the potential barrier encountered by ions as they permeate the acetylcholine receptor channel. Among the various channel geometries which have been used to represent the acetylcholine receptor channel include the cylinder and the toroidal catenary. The main reasons for those choices appear to be the facilitation of separation of the Poisson equation, r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.20.9509